Computerized Pathology

The Economist:

LOOKING for needles in haystacks is boring. But computers do not get bored. Contracting out to machines the tedious business of assessing the dangerousness of cancer cells in histological microscope slides ought thus to be an obvious thing to do. Cervical-cancer smear tests aside, however, such electronic intrusions into the pathology laboratory are limited. Grading cancer cells into “indolent” and “aggressive”, and hazarding an opinion about whether they spell a treatable condition or an untreatable one, has remained the realm of the human expert.



But not for much longer, if Daphne Koller, a computer scientist at Stanford University, and her colleagues have their way. They recently reported in Science Translational Medicine that they have written a program which can distinguish between grades of breast-cancer cell—and in a way that provides a more accurate prognosis than a human pathologist can.

Most print newspapers will be gone in five years, The desktop PC is dead; long live the tablet.

USC Annenberg News:

Over the next three years, according to Cole, the tablet will become the primary tool for personal computing. Use of a desktop PC will dwindle to only 4-6 percent of computer users – writers, gamers, programmers, analysts, scientists, and financial planners – and laptop use will decline as well.



“The tablet is such an inviting gadget,” said Cole. “The desktop PC is a ‘lean forward’ device – a tool that sits on a desk and forces uses to come to it. The tablet has a ‘lean-back’ allure — more convenient and accessible than laptops and much more engaging to use. For the vast majority of Americans, the tablet will be the computer tool of choice by the middle of the decade, while the desktop PC fades away.


“We don’t see a negative consequence in the move to tablets,” said Cole, “but the coming dominance of tablets will create major shifts in how, when, and why Americans go online – changes even more significant than the emergence of the laptop.”

……..

“Circulation of print newspapers continues to plummet, and we believe that the only print newspapers that will survive will be at the extremes of the medium – the largest and the smallest,” said Cole. It’s likely that only four major daily newspapers will continue in print form: The New York Times, USA Today, the Washington Post, and the Wall Street Journal. At the other extreme, local weekly newspapers may still survive.

“The impending death of the American print newspaper continues to raise many questions,” Cole said. “Will media organizations survive and thrive when they move exclusively to online availability? How will the changing delivery of content affect the quality and depth of journalism?”

Father Vincent Capodanno and the Meaning of “Sacrifice”

If you have never visited Semper Fidelis Memorial Chapel on the grounds of the National Museum of the Marine Corps, you have missed visiting a truly inspirational place. It is a breathtakingly beautiful building, an edifice of stone, rich wood and soaring glass that derives much of its beauty from the surrounding landscape. It is also breathtakingly simple. Nestled in the woods, it was designed to pay homage to the improvised chapels found in the field, attended by those who bear the burden of war.



Last Wednesday was nothing short of a glorious spring day in Virginia. The skies were crystal clear, without a cloud, and vibrant blue. A warm breeze stirred the air. Springtime had brought the grounds surrounding the chapel to life. I was struck by how green the trees were, and by the sound of birds singing. And on this glorious spring day, several people had gathered for a private ceremony to dedicate the “Sacrifice” window in memory of Navy chaplain, and Medal of Honor recipient, Father Vincent Capodanno.



As a former theology student, and a Marine Corps historian, I have long had an interest in those chaplains who have chosen to serve with the Fleet Marine Force. Of particular interest to me were those who served in Vietnam. It was many years ago that I first heard of the “Grunt Padre,” Father Capodanno.

Enduring lessons of Stalin’s little sparrow

Simon Sebag-Montefiore:

Svetlana Stalina, who died last week, always said that Stalin, her father, “broke my life”. Her troubled life illustrates how power coarsens, corrupts and corrodes family itself. Even in democracies, the relentless demands of power are wearying, then coarsening then corrupting. In the long reigns of despots, the more absolute, the more corrosive. The gentle ties of family are ground to dust by steel wheels of power. Men of power such as a Stalin or Hitler usually see themselves as selfless, lone knights riding with swords drawn into hostile territory. Even for those such as Colonel Gaddafi, Saddam Hussein or the Assads for whom politics is dynastic, power is paramount.

In the end, as we saw in Gaddafi’s downfall, the sons were expected to sacrifice themselves on the pyre of his narcissistic megalomania. Saddam struggled to hold the balance between the rivalries of his own diabolical princelings – his daughters were squeezed in this filial vice and in the ultimate poisoning of family life, he allowed his sons to murder his sons-in-law. The Assads have been cursed by familial rivalries. Gaddafi groomed several atrocious sons for power, even when they plotted against him – but all were sacrificed in his Bedouin hybrid of Saharan götterdämerung and Arabic King Lear.

Berlin Tech Startups

Der Spiegel:

As Berlin’s tech scene continues to grow, investors are beginning to take notice. Venture capital is flooding into the city and many funds are setting up shop locally. But with German investors still wary of the tech scene following the dot-bomb implosion a decade ago, some wonder if it will be enough.

The Wipeout Gene

Bijal P. Trivedi:

Outside Tapachula, Chiapas, Mexico—10 miles from Guatemala. To reach the cages, we follow the main highway out of town, driving past soy, cocoa, banana and lustrous dark-green mango plantations thriving in the rich volcanic soil. Past the tiny village of Rio Florido the road degenerates into an undulating dirt tract. We bump along on waves of baked mud until we reach a security checkpoint, guard at the ready. A sign posted on the barbed wire–enclosed compound pictures a mosquito flanked by a man and woman: Estos mosquitos genéticamente modificados requieren un manejo especial, it reads. We play by the rules.

Inside, cashew trees frame a cluster of gauzy mesh cages perched on a platform. The cages hold thousands of Aedes aegypti mosquitoes—the local species, smaller and quieter than the typical buzzing specimens found in the U.S. At 7 a.m., the scene looks ethereal: rays of sunlight filter through layers of mesh creating a glowing, yellow hue. Inside the cages, however, genetically modified mosquitoes are waging a death match against the locals, an attempted genocide-by-mating that has the potential to wipe out dengue fever, one of the world’s most troublesome, aggressive diseases.

Throughout a swath of subtropical and tropical countries, four closely related dengue viruses infect about 100 million people annually, causing a spectrum of illness—from flu-like aches to internal hemorrhaging, shock and death. No vaccine or cure exists. As with other mosquito-borne diseases, the primary public health strategy is to prevent people from being bitten. To that end, authorities attempt to rid neighborhoods of standing water where the insects breed, spray with insecticides, and distribute bed nets and other low-tech mosquito blockers. They pursue containment, not conquest.

The euro zone Is this really the end? Unless Germany and the ECB move quickly, the single currency’s collapse is looming

The Economist:

EVEN as the euro zone hurtles towards a crash, most people are assuming that, in the end, European leaders will do whatever it takes to save the single currency. That is because the consequences of the euro’s destruction are so catastrophic that no sensible policymaker could stand by and let it happen.

A euro break-up would cause a global bust worse even than the one in 2008-09. The world’s most financially integrated region would be ripped apart by defaults, bank failures and the imposition of capital controls (see article). The euro zone could shatter into different pieces, or a large block in the north and a fragmented south. Amid the recriminations and broken treaties after the failure of the European Union’s biggest economic project, wild currency swings between those in the core and those in the periphery would almost certainly bring the single market to a shuddering halt. The survival of the EU itself would be in doubt.

Idea of civilians using drone aircraft may soon fly with FAA

WJ Hennigan:

Drone aircraft, best known for their role in hunting and destroying terrorist hide-outs in Afghanistan, may soon be coming to the skies near you.

Police agencies want drones for air support to spot runaway criminals. Utility companies believe they can help monitor oil, gas and water pipelines. Farmers think drones could aid in spraying their crops with pesticides.

“It’s going to happen,” said Dan Elwell, vice president of civil aviation at the Aerospace Industries Assn. “Now it’s about figuring out how to safely assimilate the technology into national airspace.”

Residence Immobility

Richard Florida:

A smaller share of Americans moved last year that at any time on record, as I noted in a previous post. Nearly six in ten Americans live in the state where they were born, according to the U.S. Census bureau. But there is considerable variation from state to state, as the map (above) by Zara Matheson of the Martin Prosperity Institute shows. More than three quarters of the people in Louisiana (78.9 percent), Michigan (76.6 percent) and Ohio (75.1 percent) were born there, as opposed to just 24.3 percent of Nevadans, 35.2 percent of Floridians, 37.2 percent of the residents of Washington, D.C., and 37.7 percent of Arizonans. A high level of home-grown residents is also indicative of a lack of inflow of new people.

Looking back on USMC thanksgivings, reminding us of things for which we should be grateful

“Fabius Maximus”:

Summary: a guest post by Beth Crumley, a Marine Corp retrospective about Thanksgivings past. This reminds of how much we have to be grateful before, and the price paid for our liberty and prosperity. Reposted with permission from the Marine Corps Association website.

I love this time of year. I love walking outside on a crisp, autumn morning and hearing the leaves crunch under my feet, and the smell of a wood fire in the air. It’s a reflective time…a time to take stock of what’s important in our lives. This weekend I was happily engaged in some pre-Thanksgiving tasks. I put a large pot of poultry stock on to cook, made pastry dough and even roasted off some pumpkins for pie. Later, while sitting at my desk, I looked at the calendar and realized that 68 years ago the battle for Tarawa raged. I started to think about those who have served, and those who serve today, and how difficult it must be to be separated from family and friends on the holidays we hold most dear.



The Marine Corps has long taken particular care to ensure that those who cannot be with their families still celebrate Thanksgiving. In times of war, that has proven challenging.



On 26 November 1942, Thanksgiving Day, Marines were battling the Japanese on Guadalcanal. The diary of one veteran noted, “Thanksgiving…air raid siren at 3:30 A.M….very little sleep.” A history of the 1st Battalion, 11th Marines noted: